Keep each client's devices, alerts and reports cleanly separated while still managing everything from one place.
Model each client as its own site (or top-level group), so device lists, dashboards and reports can all be filtered per client without cross-contamination.
Assign engineers Editor or Viewer roles scoped to the clients they actually work on, rather than blanket access to your whole managed estate, see Set up role-based access control below.
Route each client's alerts to that client's dedicated channel or ticketing queue, so a busy client's alert volume never buries a quiet one.
Use per-site filtering when generating NIS2 audit-evidence or uptime SLA reports, so each client receives evidence for their own environment only.